This paper reports the changes of immunity in treatment of active pulmonary tuberculosis with Fuzheng Guben Pill (FGP). The chemotherapy group consisted of 11 cases of active pulmonary tuberculosis and was cured by streptomycin (SM) and isonicotinylhydrazide (INH). The FGP group consisted of 14 cases of active pulmonary tuberculosis and was cured by SM and INH in combination with FGP. After 60 days of treatment, the subtype T-cell mediated immunity in the FGP group was recovered to normal level. (OKT3: 46.07 +/- 6.92 to 54.86 +/- 8.74; OKT4: 36.14 +/- 4.79 to 41.00 +/- 4.13, etc). The chemotherapy group had no obvious immunological change after medication. It was shown that FGP had an immunological modulation in active pulmonary tuberculosis patients.