Cerebral vascular findings in PAPA syndrome: cerebral arterial vasculopathy or vasculitis and a posterior cerebral artery dissecting aneurysm

Kasra Khatibi; Jeremy J Heit; Nicholas A Telischak; Jorina M Elbers; Huy M Do

doi:10.1136/neurintsurg-2015-011753.rep

Cerebral vascular findings in PAPA syndrome: cerebral arterial vasculopathy or vasculitis and a posterior cerebral artery dissecting aneurysm

J Neurointerv Surg. 2016 Aug;8(8):e29. doi: 10.1136/neurintsurg-2015-011753.rep. Epub 2015 Jun 29.

Authors

Kasra Khatibi¹, Jeremy J Heit², Nicholas A Telischak², Jorina M Elbers¹, Huy M Do³

Affiliations

¹ Department of Neurology, Stanford University, Stanford, California, USA.
² Department of Radiology, Stanford University, Stanford, California, USA.
³ Departments of Radiology and Neurosurgery, Stanford University, Stanford, California, USA.

PMID: 26122324
DOI: 10.1136/neurintsurg-2015-011753.rep

Abstract

A young patient with PAPA (pyogenic arthritis, pyoderma gangrenosum, and acne) syndrome developed an unusual cerebral arterial vasculopathy/vasculitis (CAV) that resulted in subarachnoid hemorrhage from a ruptured dissecting posterior cerebral artery (PCA) aneurysm. This aneurysm was successfully treated by endovascular coil sacrifice of the affected segment of the PCA. The patient made an excellent recovery with no significant residual neurologic deficit.

Keywords: Aneurysm; Angiography; Brain; Coil; Vasculitis.

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Publication types

Case Reports

MeSH terms

Acne Vulgaris / diagnostic imaging*
Acne Vulgaris / surgery
Aortic Dissection / diagnostic imaging*
Aortic Dissection / surgery
Arthritis, Infectious / diagnostic imaging*
Arthritis, Infectious / surgery
Cerebral Angiography
Diagnosis, Differential
Endovascular Procedures / methods
Humans
Intracranial Aneurysm / diagnostic imaging*
Intracranial Aneurysm / surgery
Magnetic Resonance Angiography
Methicillin-Resistant Staphylococcus aureus
Posterior Cerebral Artery / diagnostic imaging*
Posterior Cerebral Artery / surgery
Pyoderma Gangrenosum / diagnostic imaging*
Pyoderma Gangrenosum / surgery
Staphylococcal Infections / complications
Subarachnoid Hemorrhage / diagnostic imaging
Subarachnoid Hemorrhage / surgery
Treatment Outcome
Vasculitis, Central Nervous System / diagnostic imaging*
Vasculitis, Central Nervous System / surgery

Supplementary concepts

Pyogenic arthritis, pyoderma gangrenosum, and acne