Bilateral Lung Transplantation From a Donor With Heparin-Induced Thrombocytopenia

Joshua S Jolissaint; Daniel P Mulloy; Julia C Swanson; Dana P Albon; Christine L Lau

doi:10.1016/j.athoracsur.2015.02.117

Bilateral Lung Transplantation From a Donor With Heparin-Induced Thrombocytopenia

Ann Thorac Surg. 2015 Jul;100(1):e1-3. doi: 10.1016/j.athoracsur.2015.02.117.

Authors

Joshua S Jolissaint¹, Daniel P Mulloy², Julia C Swanson², Dana P Albon³, Christine L Lau⁴

Affiliations

¹ University of Virginia School of Medicine, Charlottesville, Virginia.
² Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia.
³ Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia.
⁴ Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia. Electronic address: cll2y@virginia.edu.

PMID: 26140799
DOI: 10.1016/j.athoracsur.2015.02.117

Abstract

We report the case of a 46-year-old male patient with a history of cystic fibrosis who received bilateral lung transplantation from a donor who died secondary to complications of heparin-induced thrombocytopenia. Postoperatively, he exhibited transient focal neurologic deficits and radiographic evidence of multiple cortical and subcortical infarctions. He was treated with a combination of fondaparinux and standard immunosuppressive therapy, made a full recovery, and experienced significantly improved lung function compared to pretransplantation capacity.

Publication types

Case Reports

MeSH terms

Cystic Fibrosis / surgery*
Heparin / adverse effects*
Humans
Lung Transplantation* / methods
Male
Middle Aged
Postoperative Complications / etiology*
Thrombocytopenia / chemically induced*
Thrombocytopenia / complications*
Tissue Donors

Substances

Heparin