Evaluation of a new lateral flow test for detection of Streptococcus pneumoniae and Legionella pneumophila urinary antigen

J Microbiol Methods. 2015 Sep:116:33-6. doi: 10.1016/j.mimet.2015.06.014. Epub 2015 Jul 2.

Abstract

Pneumonia is a major cause of morbidity and mortality worldwide. Early diagnosis of the etiologic agent is important in order to choose the correct antibiotic treatment. In this study we evaluated the first commercial combined test for the agents of pneumococcal pneumonia and Legionnaires' disease based on urinary antigen detection, the ImmuView® Streptococcus pneumoniae and Legionella pneumophila Urinary Antigen Test. In this evaluation, the new test had a significantly higher sensitivity than the BinaxNOW® lateral flow tests and the Binax® EIA test. This identifies the ImmuView® S. pneumoniae and L. pneumophila Urinary Antigen Test as a fast and sensitive point of care test for identification of the infectious agent in a major group of patients with pneumonia.

Keywords: Legionella pneumophila; Pneumonia; Streptococcus pneumoniae; Urinary Antigen Test.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Bacterial / urine*
  • Female
  • Humans
  • Legionella pneumophila / immunology*
  • Legionella pneumophila / isolation & purification*
  • Legionnaires' Disease / diagnosis
  • Middle Aged
  • Pneumonia, Pneumococcal / diagnosis
  • Point-of-Care Testing
  • Reagent Kits, Diagnostic / standards
  • Sensitivity and Specificity
  • Streptococcus pneumoniae / immunology*
  • Streptococcus pneumoniae / isolation & purification*

Substances

  • Antigens, Bacterial
  • Reagent Kits, Diagnostic