Oral Everolimus for Treatment of a Giant Left Ventricular Rhabdomyoma in a Neonate-Rapid Tumor Regression Documented by Real Time 3D Echocardiography

Robert Wagner; Frank Thomas Riede; Hiroshi Seki; Frauke Hornemann; Steffen Syrbe; Ingo Daehnert; Michael Weidenbach

doi:10.1111/echo.13015

Oral Everolimus for Treatment of a Giant Left Ventricular Rhabdomyoma in a Neonate-Rapid Tumor Regression Documented by Real Time 3D Echocardiography

Echocardiography. 2015 Dec;32(12):1876-9. doi: 10.1111/echo.13015. Epub 2015 Jul 22.

Authors

Robert Wagner¹, Frank Thomas Riede¹, Hiroshi Seki², Frauke Hornemann³, Steffen Syrbe³, Ingo Daehnert¹, Michael Weidenbach¹

Affiliations

¹ Department of Pediatric Cardiology, University of Leipzig, Heart Center, Leipzig, Germany.
² Department of Cardiac Surgery, University of Leipzig, Heart Center, Leipzig, Germany.
³ Department of Pediatric Neurology, University of Leipzig, Leipzig, Germany.

PMID: 26199144
DOI: 10.1111/echo.13015

Abstract

The presented case reports on successful treatment with everolimus in a neonate with left ventricular giant rhabdomyoma. The authors used a different dosage regime compared to literature and documented rapid tumor regression by 3D echocardiography.

Keywords: cardiac tumor; congenital heart diseases; left ventricular outflow obstruction; real time imaging techniques; three-dimensional transthoracic echocardiography.

Publication types

Case Reports

MeSH terms

Administration, Oral
Antineoplastic Agents / administration & dosage
Computer Systems
Echocardiography, Three-Dimensional / methods*
Everolimus / administration & dosage*
Heart Neoplasms / diagnostic imaging*
Heart Neoplasms / drug therapy*
Heart Ventricles / diagnostic imaging
Humans
Infant, Newborn
Infant, Newborn, Diseases / diagnostic imaging
Infant, Newborn, Diseases / drug therapy
Remission Induction / methods
Rhabdomyoma / diagnostic imaging*
Rhabdomyoma / drug therapy*
Treatment Outcome

Substances

Antineoplastic Agents
Everolimus