Abstract
A highly specific fluorescent probe (OC9) was discovered exhibiting tubulin-specific affinity fluorescence, which allowed selective labeling of cellular tubulin in microtubules. Moreover, distinct tubulin dynamics in various cellular bio-settings such as drug resistant or epithelial-mesenchymal transition (EMT) cancer cells were directly observed for the first time via OC9 staining.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aniline Compounds / chemistry*
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Cell Line, Tumor
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Chalcones / chemistry*
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Drug Resistance, Neoplasm
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Epithelial-Mesenchymal Transition
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Fluorescent Dyes / chemistry*
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Humans
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MCF-7 Cells
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Microscopy, Fluorescence
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Microtubules / chemistry
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Microtubules / metabolism
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Tubulin / chemistry*
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Tubulin / metabolism
Substances
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3-(4-(dimethylamino)phenyl)-1-(4'-fluoro(1,1'-biphenyl)-2-yl)prop-2-en-1-one
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Aniline Compounds
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Chalcones
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Fluorescent Dyes
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Tubulin