CML in pregnancy: A case report using leukapheresis and literature review

Mahender Yellu; Sue Pinkard; Abhimanyu Ghose; Stephen Medlin

doi:10.1016/j.transci.2015.05.009

CML in pregnancy: A case report using leukapheresis and literature review

Transfus Apher Sci. 2015 Dec;53(3):289-92. doi: 10.1016/j.transci.2015.05.009. Epub 2015 Jul 14.

Authors

Mahender Yellu¹, Sue Pinkard², Abhimanyu Ghose¹, Stephen Medlin³

Affiliations

¹ Division of Hematology/Oncology, Stem Cell Transplantation, University of Cincinnati, Cincinnati, OH, USA.
² Department of Therapeutic Apheresis, Hoxworth Blood Center, University of Cincinnati, Cincinnati, OH, USA.
³ Division of Hematology/Oncology, Stem Cell Transplantation, University of Cincinnati, Cincinnati, OH, USA. Electronic address: medlinsn@ucmail.uc.edu.

PMID: 26231323
DOI: 10.1016/j.transci.2015.05.009

Abstract

Chronic myelogenous leukemia (CML) complicating pregnancy is uncommon. Literature search demonstrates only a few case reports and some case series but large studies are lacking due to its uncommon presentation. Management of these patients is particularly challenging due to limited available options as several chemotherapy drugs could potentially lead to adverse outcomes and fetal malformations. Leukapheresis has been used in these situations; however paucity of data exists regarding the outcome and complications associated with the procedure. Using leukapheresis alone for extended period to manage CML during pregnancy is also rare. Here we report a case of CML complicating pregnancy which was successfully managed utilizing leukapheresis, followed by a review of literature addressing this controversial issue.

Keywords: CML; Chemotherapy; Leukapheresis; Pregnancy.

Publication types

Case Reports
Review

MeSH terms

Adult
Female
Humans
Leukapheresis / methods*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy*
Pregnancy
Pregnancy Complications, Hematologic / therapy*
Pregnancy Complications, Neoplastic / therapy*