Immunologic and Hematological Abnormalities in Necrotizing Enterocolitis

Akhil Maheshwari

doi:10.1016/j.clp.2015.04.014

Immunologic and Hematological Abnormalities in Necrotizing Enterocolitis

Clin Perinatol. 2015 Sep;42(3):567-85. doi: 10.1016/j.clp.2015.04.014. Epub 2015 May 13.

Author

Akhil Maheshwari¹

Affiliation

¹ Department of Pediatrics, Morsani College of Medicine, Tampa, FL 33606, USA; Department of Molecular Medicine, Morsani College of Medicine, Tampa, FL 33612, USA; Department of Community and Family Health, College of Public Health, University of South Florida, Tampa, FL 33612, USA. Electronic address: akhilm@health.usf.edu.

Abstract

Necrotizing enterocolitis (NEC) is a leading cause of mortality in preterm infants. This article reviews the immunologic and hematological abnormalities typically seen in infants with NEC, such as elevated plasma cytokine levels, thrombocytopenia, increased or decreased neutrophil counts, low monocyte counts, and anemia. Some of these findings may provide important diagnostic and prognostic information.

Keywords: Blood counts; Inflammation; Macrophages; Monocytes; NEC; Neutrophils; Platelets; Signaling.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Enterocolitis, Necrotizing* / blood
Enterocolitis, Necrotizing* / complications
Enterocolitis, Necrotizing* / immunology
Hematologic Diseases* / blood
Hematologic Diseases* / etiology
Hematologic Diseases* / immunology
Humans
Immunity, Innate*
Infant, Newborn

Abstract

Publication types

MeSH terms

Grants and funding