Therapeutic potential of chemokine signal inhibition for metastatic breast cancer

Pharmacol Res. 2015 Oct:100:266-70. doi: 10.1016/j.phrs.2015.08.004. Epub 2015 Aug 11.

Abstract

Metastatic breast cancer is incurable by current therapies including chemotherapy and immunotherapy. Accumulating evidence indicates that tumor-infiltrating macrophages promote establishment of the lethal metastatic foci and contribute to therapeutic resistance. Recent studies suggest that the accumulation of these macrophages is regulated by a chemokine network established in the tumor microenvironment. In this perspective paper, we elaborate on the chemokine signals that can attract monocytes/macrophages to the site of metastasis, and discuss whether inhibition of these chemokine signals can represent a new therapeutic strategy for metastatic breast cancer.

Keywords: Breast cancer; Chemokine; Macrophage; Metastasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / metabolism
  • Chemokines / metabolism*
  • Female
  • Humans
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Tumor Microenvironment / drug effects

Substances

  • Chemokines