Seizing control of epileptic activity can improve outcome

Epilepsia. 2015 Oct;56(10):1482-5. doi: 10.1111/epi.13109. Epub 2015 Aug 21.

Abstract

In epileptic encephalopathy, the seizures and interictal epileptiform activity create additional neurocognitive dysfunction beyond that due to the underlying etiology. Treatment leading to a reduction in seizures or interictal abnormalities may help improve neurocognitive function in these situations. The focus of our discussion is reviewing data that support the concept that treatment can impact outcome independent of the etiology in some cases.

Keywords: Cognitive impairment; Epilepsy; Epileptic encephalopathy; Humans; Treatment.

Publication types

  • Review

MeSH terms

  • Cognition Disorders / etiology*
  • Epilepsy / complications*
  • Epilepsy / genetics
  • Humans
  • Mutation / genetics
  • NAV1.1 Voltage-Gated Sodium Channel / genetics
  • Seizures / etiology*
  • Seizures / genetics
  • Seizures / therapy*

Substances

  • NAV1.1 Voltage-Gated Sodium Channel
  • SCN1A protein, human