DNA Immunization for HIV Vaccine Development

Yuxin Chen; Shixia Wang; Shan Lu

doi:10.3390/vaccines2010138

DNA Immunization for HIV Vaccine Development

Vaccines (Basel). 2014 Feb 25;2(1):138-59. doi: 10.3390/vaccines2010138.

Authors

Yuxin Chen¹, Shixia Wang², Shan Lu³

Affiliations

¹ Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. yuxin.chen@umassmed.edu.
² Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. shixia.wang@umassmed.edu.
³ Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. shan.lu@umassmed.edu.

Abstract

DNA vaccination has been studied in the last 20 years for HIV vaccine research. Significant experience has been accumulated in vector design, antigen optimization, delivery approaches and the use of DNA immunization as part of a prime-boost HIV vaccination strategy. Key historical data and future outlook are presented. With better understanding on the potential of DNA immunization and recent progress in HIV vaccine research, it is anticipated that DNA immunization will play a more significant role in the future of HIV vaccine development.

Keywords: AIDS; DNA immunization; HIV-1; vaccine.

Publication types

Review

Abstract

Publication types

Grants and funding