Melatonin Lulling Th17 Cells to Sleep

Jacob S Lee; Daniel J Cua

doi:10.1016/j.cell.2015.08.054

Melatonin Lulling Th17 Cells to Sleep

Cell. 2015 Sep 10;162(6):1212-4. doi: 10.1016/j.cell.2015.08.054.

Authors

Jacob S Lee¹, Daniel J Cua²

Affiliations

¹ IMR Pathway Biology, Merck Research Laboratory, 901 California Avenue, Palo Alto, CA 94304, USA. Electronic address: jacob.lee@merck.com.
² IMR Pathway Biology, Merck Research Laboratory, 901 California Avenue, Palo Alto, CA 94304, USA. Electronic address: daniel.cua@merck.com.

PMID: 26359982
DOI: 10.1016/j.cell.2015.08.054

Abstract

In this issue, Farez et al. report that the circadian hormone melatonin, whose levels vary with seasonal changes in night length, shifts the immune response toward an anti-inflammatory state that may explain the seasonal variability of multiple sclerosis disease activity.

Publication types

Comment

MeSH terms

Animals
Female
Humans
Male
Melatonin / metabolism*
Multiple Sclerosis / immunology*
Multiple Sclerosis / pathology*

Substances

Melatonin