U-insertion/deletion RNA editing multiprotein complexes and mitochondrial ribosomes in Leishmania tarentolae are located in antipodal nodes adjacent to the kinetoplast DNA

Mitochondrion. 2015 Nov:25:76-86. doi: 10.1016/j.mito.2015.10.006. Epub 2015 Oct 14.

Abstract

We studied the intramitochondrial localization of several multiprotein complexes involved in U-insertion/deletion RNA editing in trypanosome mitochondria. The editing complexes are located in one or two antipodal nodes adjacent to the kinetoplast DNA (kDNA) disk, which are distinct from but associated with the minicircle catenation nodes. In some cases the proteins are in a bilateral sheet configuration. We also found that mitoribosomes have a nodal configuration. This type of organization is consistent with evidence for protein and RNA interactions of multiple editing complexes to form an ~40S editosome and also an interaction of editosomes with mitochondrial ribosomes.

Keywords: Antipodal node; Editing; Kinetoplast; Leishmania; RNA; Trypanosome.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • DNA, Kinetoplast / metabolism*
  • Leishmania / enzymology*
  • Leishmania / metabolism
  • Mitochondria / enzymology*
  • Mitochondria / metabolism
  • Mitochondrial Ribosomes / metabolism*
  • Multiprotein Complexes / metabolism*
  • RNA Editing*

Substances

  • DNA, Kinetoplast
  • Multiprotein Complexes