Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis

FEBS J. 2016 Mar;283(6):986-92. doi: 10.1111/febs.13569. Epub 2015 Nov 12.

Abstract

The Pex1 and Pex6 proteins are members of the AAA family of ATPases and are involved in peroxisome biogenesis. Recently, cryo-electron microscopy structures of the Pex1-Pex6 complex in different nucleotide states have been determined. This Structural Snapshot describes the structural features of the complex and their implications for its function, as well as questions that still await answers.

Keywords: AAA ATPases; Pex1-Pex6 complex; cryo-electron microscopy; peroxisome biogenesis; single-particle analysis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATPases Associated with Diverse Cellular Activities
  • Adenosine Triphosphatases / chemistry*
  • Adenosine Triphosphatases / metabolism*
  • Cryoelectron Microscopy
  • Humans
  • Membrane Proteins / chemistry*
  • Membrane Proteins / metabolism*
  • Models, Molecular
  • Multienzyme Complexes / chemistry
  • Multienzyme Complexes / metabolism
  • Peroxisomes / enzymology*
  • Protein Conformation
  • Protein Interaction Domains and Motifs
  • Protein Subunits
  • Static Electricity

Substances

  • Membrane Proteins
  • Multienzyme Complexes
  • Protein Subunits
  • Adenosine Triphosphatases
  • ATPases Associated with Diverse Cellular Activities
  • PEX1 protein, human
  • PEX6 protein, human