Replication Origin Specification Gets a Push

Mol Cell. 2015 Dec 3;60(5):711-712. doi: 10.1016/j.molcel.2015.11.012.

Abstract

During the gap between G1 and S phases when replication origins are licensed and fired, it is possible that DNA translocases could disrupt pre-replicative complexes (pre-RCs). In this issue of Molecular Cell, Gros et al. (2015) find that pre-RCs can be pushed along DNA and retain the ability to support replication.

Publication types

  • Comment

MeSH terms

  • Minichromosome Maintenance Proteins / metabolism*
  • Replication Origin*
  • Saccharomyces cerevisiae / genetics*

Substances

  • Minichromosome Maintenance Proteins