Voxel-Based Morphometry for Separation of Schizophrenia From Other Types of Psychosis in First-Episode Psychosis: Diagnostic Test Review

Lena Palaniyappan; Nicola Maayan; Hanna Bergman; Clare Davenport; Clive E Adams; Karla Soares-Weiser

doi:10.1093/schbul/sbv189

Voxel-Based Morphometry for Separation of Schizophrenia From Other Types of Psychosis in First-Episode Psychosis: Diagnostic Test Review

Schizophr Bull. 2016 Mar;42(2):277-8. doi: 10.1093/schbul/sbv189. Epub 2016 Jan 5.

Authors

Lena Palaniyappan¹, Nicola Maayan², Hanna Bergman², Clare Davenport³, Clive E Adams⁴, Karla Soares-Weiser⁵

Affiliations

¹ Department of Psychiatry & Robarts Research Institute, University of Western Ontario, London, Ontario, Canada; lpalaniy@uwo.ca.
² Enhance Reviews Ltd, Wantage, UK;
³ Public Health, Epidemiology and Biostatistics, University of Birmingham, Birmingham, UK;
⁴ Cochrane Schizophrenia Group, The University of Nottingham, Nottingham, UK;
⁵ Cochrane Editorial Unit, Cochrane, London, UK.

Abstract

Subtle but widespread deficit in the cortical and subcortical grey matter is a consistent neuroimaging observation in schizophrenia. Several studies have used voxel based morphometry (VBM) to investigate the nature of this structural deficit. We conducted a diagnostic test review to explore the diagnostic potential of VBM in differentiating schizophrenia from other types of first-episode psychoses.

Keywords: diagnostic accuracy; morphometry; neuroanatomy; structural MRI.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain / pathology*
Humans
Magnetic Resonance Imaging / standards*
Neuroimaging / standards*
Psychotic Disorders / diagnosis*
Psychotic Disorders / pathology
Schizophrenia / diagnosis*
Schizophrenia / pathology