Kinetic Diversity of Striatal Dopamine: Evidence from a Novel Protocol for Voltammetry

ACS Chem Neurosci. 2016 May 18;7(5):662-7. doi: 10.1021/acschemneuro.6b00020. Epub 2016 Mar 1.

Abstract

In vivo voltammetry reveals substantial diversity of dopamine kinetics in the rat striatum. To substantiate this kinetic diversity, we evaluate the temporal distortion of dopamine measurements arising from the diffusion-limited adsorption of dopamine to voltammetric microelectrodes. We validate two mathematical procedures for correcting adsorptive distortion, both of which substantiate that dopamine's apparent kinetic diversity is not an adsorption artifact.

Keywords: Dopamine; kinetic diversity; modeling; restricted diffusion; voltammetry.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Corpus Striatum / metabolism*
  • Dopamine / metabolism*
  • Electrochemical Techniques / methods*
  • Male
  • Pharmacokinetics
  • Prodrugs / pharmacokinetics*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Prodrugs
  • Dopamine