When (distant) relatives stay too long: implications for cancer medicine

Genome Biol. 2016 Feb 24:17:34. doi: 10.1186/s13059-016-0906-3.

Diego Chowell^{1

2}, Amy M Boddy^{3

4}, Diego Mallo¹, Marc Tollis¹, Carlo C Maley^{5

6}

¹ Biodesign Institute, Arizona State University, Tempe, Arizona, 85281, USA.
² Simon A. Levin Mathematical, Computational and Modeling Sciences Center, Arizona State University, Tempe, Arizona, 85281, USA.
³ Department of Psychology, Arizona State University, Tempe, Arizona, 85281, USA.
⁴ Center for Evolution and Cancer, University of California San Francisco, San Francisco, California, 94158, USA.
⁵ Biodesign Institute, Arizona State University, Tempe, Arizona, 85281, USA. maley@asu.edu.
⁶ Center for Evolution and Cancer, University of California San Francisco, San Francisco, California, 94158, USA. maley@asu.edu.

Abstract

Whole-genome analyses of human medulloblastomas show that the dominant clone at relapse is present as a rare subclone at primary diagnosis.