State-of-the-art of regulatory dendritic cells in cancer

Abstract

Dendritic cells (DCs) with robust immunosuppressive activity are commonly found in the microenvironment of advanced solid tumors. These innate immune cells are generically termed regulatory DCs and include various subsets such as plasmacytoid, conventional and monocyte-derived/inflammatory populations whose normal function is subverted by tumor-derived signals. This review summarizes recent findings on the nature and function of regulatory DCs, their relationship with other myeloid subsets and unique therapeutic opportunities to abrogate malignant progression through their targeting.

Keywords: Dendritic cell; Emergency myelopoiesis; Immunosuppression; Tumor immunology; Tumor microenvironment.