Transcriptome Encyclopedia of Early Human Development

Anna Sahakyan; Kathrin Plath

doi:10.1016/j.cell.2016.04.042

Transcriptome Encyclopedia of Early Human Development

Cell. 2016 May 5;165(4):777-9. doi: 10.1016/j.cell.2016.04.042.

Authors

Anna Sahakyan¹, Kathrin Plath²

Affiliations

¹ David Geffen School of Medicine, Department of Biological Chemistry, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, UCLA Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA.
² David Geffen School of Medicine, Department of Biological Chemistry, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, UCLA Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: kplath@mednet.ucla.edu.

Abstract

Our understanding of human pre-implantation development is limited by the availability of human embryos and cannot completely rely on mouse studies. Petropoulos et al. now provide an extensive transcriptome analysis of a large number of human pre-implantation embryos at single-cell resolution, revealing previously unrecognized features unique to early human development.

Publication types

Comment

MeSH terms

Animals
Blastocyst*
Embryo Implantation
Embryonic Development
Gene Expression Profiling
Humans
Transcriptome*

Grants and funding

R01 GM115233/GM/NIGMS NIH HHS/United States