H3K9me3-mediated repression of KLF6: Discovering a novel tumor suppressor in liposarcoma using a systematic epigenomic approach

Emily Z Keung; Kunal Rai

doi:10.1080/23723556.2015.1093691

H3K9me3-mediated repression of KLF6: Discovering a novel tumor suppressor in liposarcoma using a systematic epigenomic approach

Mol Cell Oncol. 2015 Oct 29;3(3):e1093691. doi: 10.1080/23723556.2015.1093691. eCollection 2016 May.

Authors

Emily Z Keung¹, Kunal Rai²

Affiliations

¹ Department of Surgery, Brigham and Women's Hospital , Boston, MA, USA.
² Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.

Abstract

The pathogenesis of well-differentiated and dedifferentiated liposarcoma is poorly understood. We recently reported Kruppel-like factor 6 (KLF6) as a histone H3 lysine 9 trimethyl (H3K9me3)-regulated and differentially expressed transcription factor serving a previously unappreciated tumor suppressor role in liposarcoma. Mechanistically, KLF6 may drive adipocytic differentiation through increased expression of known regulators of adipogenesis.

Keywords: Dedifferentiated; H3K9me3; KLF6; epigenetics; liposarcoma; well differentiated.

Abstract

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