Tracing the tissue of origin of plasma DNA-feasibility and implications

Yuk Ming Dennis Lo; Wai Kei Jacky Lam

doi:10.1111/nyas.13163

Tracing the tissue of origin of plasma DNA-feasibility and implications

Ann N Y Acad Sci. 2016 Jul;1376(1):14-7. doi: 10.1111/nyas.13163. Epub 2016 Aug 15.

Authors

Yuk Ming Dennis Lo^{1

2}, Wai Kei Jacky Lam³

Affiliations

¹ Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China. loym@cuhk.edu.hk.
² Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China. loym@cuhk.edu.hk.
³ Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.

PMID: 27525383
DOI: 10.1111/nyas.13163

Abstract

Scientists have been exploring cell-free DNA in plasma for a wider clinical application in addition to noninvasive prenatal testing. Tracing the tissue of origin of plasma DNA is the next important step. In this perspective, we discuss different approaches recently reported for tracing the tissue of origin of plasma DNA and the implications.

Keywords: epigenetics; liquid biopsy; methylation; plasma DNA; tumor markers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA / blood*
DNA Methylation / genetics
Epigenesis, Genetic
Feasibility Studies
Humans
Organ Specificity*

Substances

DNA