Organophosphorus-mediated N-N bond formation: facile access to 3-amino-2H-indazoles

Org Biomol Chem. 2016 Sep 28;14(36):8520-8. doi: 10.1039/c6ob01544a. Epub 2016 Aug 19.

Abstract

A convenient and efficient strategy has been devised to access 3-amino-2H-indazole derivatives in two steps from readily available starting materials. The conversion of 2-nitrobenzonitriles to substituted benzamidines followed by an organophosphorus-mediated reductive cyclization and a subsequent N-N bond formation afforded 3-amino-2H-indazoles in good to excellent yields.