Influence of interleukin-18 gene polymorphisms on acute pancreatitis susceptibility in a Chinese population

Genet Mol Res. 2016 Aug 26;15(3). doi: 10.4238/gmr.15038394.

Abstract

We investigate the relationship between IL-18 -607C/A and -137G/C genetic polymorphisms and development of acute pancreatitis in a Chinese population. A total of 153 patients were consecutively recruited from the First Affiliated Hospital of Chongqing Medical University between January 2013 and November 2014. Genotyping of IL-18 -607C/A and -137G/C variants was performed using the polymerase chain reaction-restriction fragment length polymorphism method. We observed a significant difference between acute pancreatitis patients and control subjects with respect to age (t = 2.15, P = 0.02), gender (chi-square = 3.95, P = 0.04), body mass index (t = 5.85, P < 0.001), and alcohol consumption (chi-square = 9.74, P = 0.002). Using chi-square tests, we found that the genotype distributions of IL-18 -607C/A (chi-square = 0.81, P = 0.67) and -137G/C (chi-square = 1.16, P = 0.56) polymorphisms did not differ between the acute pancreatitis and control groups. Genotype frequencies of these variants were consistent with Hardy-Weinberg equilibrium in both patient and control groups. In addition, logistic regression analysis failed to identify a significant association between these polymorphisms and acute pancreatitis risk. Our study firstly examined their association in a Chinese population, and we suggest that the IL-18 -607C/A and -137G/ C polymorphisms do not influence susceptibility to acute pancreatitis in the Chinese population studied in the present study.

MeSH terms

  • Acute Disease
  • Age Factors
  • Aged
  • Alleles
  • Asian People
  • Body Mass Index
  • Case-Control Studies
  • Disease Susceptibility
  • Female
  • Gene Expression
  • Gene Frequency
  • Genetic Linkage
  • Genotype*
  • Humans
  • Interleukin-18 / genetics*
  • Male
  • Middle Aged
  • Pancreatitis / ethnology
  • Pancreatitis / genetics*
  • Pancreatitis / pathology
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic*
  • Sex Factors

Substances

  • Interleukin-18