JAK-STAT Signaling Jump Starts the Hair Cycle

Etienne Wang; Sivan Harel; Angela M Christiano

doi:10.1016/j.jid.2016.08.029

JAK-STAT Signaling Jump Starts the Hair Cycle

J Invest Dermatol. 2016 Nov;136(11):2131-2132. doi: 10.1016/j.jid.2016.08.029.

Authors

Etienne Wang¹, Sivan Harel², Angela M Christiano³

Affiliations

¹ Department of Dermatology, Columbia University, New York, New York, USA. Electronic address: ew2445@cumc.columbia.edu.
² Department of Dermatology, Columbia University, New York, New York, USA.
³ Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA. Electronic address: amc65@cumc.columbia.edu.

PMID: 27772548
DOI: 10.1016/j.jid.2016.08.029

Abstract

Legrand et al show that JAK/STAT5 signaling in the dermal papilla is required for anagen onset in the murine hair cycle. Interestingly, others have shown that JAK-inhibition is able to induce telogen-to-anagen transition in wild-type mice. This apparent contradiction highlights the complexity of interactions within the hair follicle, and encourages further discussion on the role of JAK-STAT signaling in the various stem cell niches of the hair follicle.

Publication types

Comment

MeSH terms

Animals
Cell Cycle
Gene Expression Regulation*
Hair Diseases / genetics*
Hair Diseases / metabolism
Hair Diseases / pathology
Hair Follicle / metabolism
Hair Follicle / pathology*
Humans
Janus Kinases / biosynthesis
Janus Kinases / genetics*
STAT5 Transcription Factor / biosynthesis
STAT5 Transcription Factor / genetics*
Signal Transduction

Substances

STAT5 Transcription Factor
Janus Kinases