[Strategies for cerebrospinal fluid analysis - Integrated results report]

Nervenarzt. 2016 Dec;87(12):1271-1275. doi: 10.1007/s00115-016-0232-8.
[Article in German]

Abstract

Cerebrospinal fluid (CSF) analysis requires a combined assessment of all individual test findings in an integrated total report in order to achieve a reliable and specific diagnostic conclusion. Such a standard assessment strategy allows the identification of disease-typical result patterns and plausibility checks to avoid analytical errors. The integrated total report consists of 1) a basic CSF program with cytological and protein chemical parameters, 2) an expanded CSF program with special parameters for detection of pathogens and markers of neurodegeneration and 3) a final contextual interpretation considering methodological and clinical aspects.

Keywords: Albumins; Cerebrospinal fluid proteins; Cytology; Immunoglobulins; Serum globulins.

Publication types

  • Review

MeSH terms

  • Biomarkers / cerebrospinal fluid
  • Blood Proteins / analysis*
  • Cerebrospinal Fluid / chemistry*
  • Cerebrospinal Fluid / microbiology*
  • Clinical Laboratory Techniques / methods*
  • Diagnostic Techniques, Neurological*
  • Humans
  • Neurodegenerative Diseases / cerebrospinal fluid*
  • Neurodegenerative Diseases / diagnosis
  • Neurodegenerative Diseases / microbiology

Substances

  • Biomarkers
  • Blood Proteins