Immune modules shared by innate lymphoid cells and T cells

J Allergy Clin Immunol. 2016 Nov;138(5):1243-1251. doi: 10.1016/j.jaci.2016.09.006.

Abstract

In recent years, innate lymphoid cells (ILCs) have emerged as innate correlates to T cells. The similarities between ILCs and T cells indicate that lymphocytes of fundamentally distinct lineages can share core "immune modules" that encompass transcriptional circuitry and effector functions while using nonredundant complementary mechanisms of pattern recognition to enact these functions. We review modules currently recognized to be shared between ILCs and T cells.

Keywords: Innate lymphoid cell; T cell; adaptive; innate; lymphocyte.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Bacterial Infections / immunology
  • Helminthiasis / immunology
  • Humans
  • Immunity, Innate
  • Lymphocytes / immunology*
  • Mycoses / immunology
  • Virus Diseases / immunology