The Good and Bad of RNA:DNA Hybrids in Double-Strand Break Repair

Brian S Plosky

doi:10.1016/j.molcel.2016.11.010

The Good and Bad of RNA:DNA Hybrids in Double-Strand Break Repair

Mol Cell. 2016 Nov 17;64(4):643-644. doi: 10.1016/j.molcel.2016.11.010.

Author

Brian S Plosky¹

Affiliation

¹ Molecular Cell, Cell Press, 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, USA. Electronic address: bplosky@cell.com.

PMID: 27863224
DOI: 10.1016/j.molcel.2016.11.010

Abstract

Transcription and genome stability have somewhat of a love-hate relationship. In a recent issue of Cell, Ohle et al. (2016) demonstrate a previously unappreciated mechanism by which transcription and RNA contribute to genome stability.

Publication types

Comment

MeSH terms

DNA
DNA Breaks, Double-Stranded
DNA Damage
DNA Repair*
RNA*

Substances

RNA
DNA