Regulatory mechanisms of phosphatase of regenerating liver (PRL)-3

Biochem Soc Trans. 2016 Oct 15;44(5):1305-1312. doi: 10.1042/BST20160146.

Abstract

The phosphatase of regenerating liver (PRL)-3 is overexpressed in many human cancer types and tumor metastases when compared with healthy tissues. Different pathways and mechanisms have been suggested to modulate PRL-3 expression levels and activity, giving some valuable insights but still leaving an incomplete picture. Investigating these mechanisms could provide new targets for therapeutic drug development. Here, we present an updated overview and summarize recent findings concerning the different PRL-3 expression regulatory mechanisms and posttranslational modifications suggested to modulate the activity, localization, or stability of this phosphatase.

Keywords: PTP4A3; cancer; dual-specificity phosphatases; metastasis; post-translational modification; protein phosphatases.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enzyme Stability
  • Gene Expression Regulation, Enzymologic*
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Models, Genetic
  • Neoplasm Metastasis
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / metabolism
  • Neoplasms / enzymology
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Protein Processing, Post-Translational
  • Protein Tyrosine Phosphatases / genetics*
  • Protein Tyrosine Phosphatases / metabolism
  • Signal Transduction / genetics

Substances

  • Neoplasm Proteins
  • PTP4A3 protein, human
  • Protein Tyrosine Phosphatases