A Breakdown in Cooperativity Leads to Cardiac Identity Crisis

Ana Vujic; Ahmed I Mahmoud; Richard T Lee

doi:10.1016/j.cell.2016.11.056

A Breakdown in Cooperativity Leads to Cardiac Identity Crisis

Cell. 2016 Dec 15;167(7):1674-1676. doi: 10.1016/j.cell.2016.11.056.

Authors

Ana Vujic¹, Ahmed I Mahmoud¹, Richard T Lee²

Affiliations

¹ Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
² Department of Stem Cell and Regenerative Biology and the Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: richard_lee@harvard.edu.

PMID: 27984717
DOI: 10.1016/j.cell.2016.11.056

Abstract

Using induced pluripotent stem cells, Ang et al. elucidate how a mutation in the transcription factor GATA4 causes congenital heart disease. They find that, although the recruitment of GATA4 to cardiac super-enhancers is retained, it no longer functions in partnership with another key transcription factor, leading to misexpression of non-cardiomyocyte genes.

Publication types

Comment

MeSH terms

GATA4 Transcription Factor / genetics*
Heart
Humans
Identity Crisis*
Myocytes, Cardiac / metabolism
Transcription Factors / genetics

Substances

GATA4 Transcription Factor
Transcription Factors