Taxonomy for colorectal cancer screening promotion: Lessons from recent randomized controlled trials

Paul Ritvo; Ronald E Myers; Mardie Serenity; Samir Gupta; John M Inadomi; Beverly B Green; Anthony Jerant; Jill Tinmouth; Lawrence Paszat; Meysam Pirbaglou; Linda Rabeneck

doi:10.1016/j.ypmed.2016.12.024

Taxonomy for colorectal cancer screening promotion: Lessons from recent randomized controlled trials

Prev Med. 2017 Aug:101:229-234. doi: 10.1016/j.ypmed.2016.12.024. Epub 2016 Dec 24.

Authors

Affiliations

¹ York University, Kinesiology and Health Science, 4700 Keele St., Toronto, ON CAN M3J 1P3, Canada; Ontario Cancer Institute, Division of Epidemiology and Biostatistics, 600 University Ave., Toronto, ON CAN M5G2C4, Canada. Electronic address: pritvo@yorku.ca.
² Thomas Jefferson University, Medical Oncology, 834 Chestnut Street, Suite 413, Philadelphia, PA, USA. Electronic address: ronald.myers@jefferson.edu.
³ Sunnybrook Health Sciences Centre, Clinical Epidemiology, Toronto, ON, Canada. Electronic address: mardie.serenity@sunnybrook.ca.
⁴ San Diego Veterans Affairs Healthcare System, Department of Medicine, Section of Gastroenterology, 3350 La Jolla Village Dr, MC 111D San Diego, CA, USA. Electronic address: s1gupta@ucsd.edu.
⁵ Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: JInadomi@medicine.washington.edu.
⁶ Group Health Cooperative, Group Health Research Institute, Seattle, WA, USA. Electronic address: green.b@ghc.org.
⁷ UC Davis, Department of Family Medicine, Sacramento, CA, USA. Electronic address: afjerant@ucdavis.edu.
⁸ Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room: HG40, Toronto, ON, Canada. Electronic address: jill.tinmouth@sunnybrook.ca.
⁹ University of Toronto, Institute of Health Policy, Management & Evaluation, Toronto, ON, Canada; Institute for Clinical Evaluative Sciences, Toronto, ON, Canada. Electronic address: Lawrence@ices.on.ca.
¹⁰ York University, Kinesiology and Health Science, 4700 Keele St., Toronto, ON CAN M3J 1P3, Canada. Electronic address: meyir@yorku.ca.
¹¹ Cancer Care Ontario, Prevention and Cancer Control, Toronto, ON, Canada. Electronic address: Linda.Rabeneck@cancercare.on.ca.

PMID: 28024865
DOI: 10.1016/j.ypmed.2016.12.024

Abstract

Objective: To derive a taxonomy for colorectal cancer screening that advances Randomized Controlled Trials (RCTs) and screening uptake.

Design: Detailed publication review, multiple interviews with principal investigators (PIs) and collaboration with PIs as co-authors produced a CRCS intervention taxonomy. Semi-structured interview questions with PIs (Drs. Inadomi, Myers, Green, Gupta, Jerant and Ritvo) yielded details about trial conduct. Interview comparisons led to an iterative process informing serial interviews until a consensus was obtained on final taxonomy structure.

Results: These taxonomy headings (Engagement Sponsor, Population Targeted, Alternative Screening Tests, Delivery Methods, and Support for Test Performance (EPADS)) were used to compare studies. Exemplary insights emphasized: 1) direct test delivery to patients; 2) linguistic-ethnic matching of staff to minority subjects; and 3) authorization of navigators to schedule or refer for colonoscopies and/or distribute stool blood tests during screening promotion.

Conclusion: PIs of key RCTs (2012-2015) derived a CRCS taxonomy useful in detailed examination of CRCS promotion and design of future RCTs.

Keywords: Cancer prevention; Clinical trials; Colorectal cancer; Colorectal cancer screening; Health service research.

MeSH terms

Classification / methods*
Colorectal Neoplasms / diagnosis
Early Detection of Cancer / methods
Female
Health Promotion*
Humans
Male
Mass Screening / methods*
Occult Blood
Randomized Controlled Trials as Topic*

Grants and funding

R01 CA121125/CA/NCI NIH HHS/United States