Blood malignancies presenting with mutations at equivalent residues in RUNX1-2 suggest a common leukemogenic pathway

Leuk Lymphoma. 2017 Aug;58(8):2002-2004. doi: 10.1080/10428194.2016.1274980. Epub 2017 Jan 16.

Authors

Michele Callea¹, Fabiana Fattori², Enrico Silvio Bertini², Francisco Cammarata-Scalisi³, Francesco Callea⁴, Emanuele Bellacchio⁵

Affiliations

¹ a Unit of Dentistry , Bambino Gesù Children's Hospital, IRCCS , Rome , Italy.
² b Unit for Neuromuscular and Neurodegenerative Disorders, Laboratory of Molecular Medicine , Bambino Gesù Children's Hospital , Rome , Italy.
³ c Department of Pediatrics, Unit of Medical Genetics, Faculty of Medicine , University of The Andes , Mérida , Venezuela.
⁴ d Department of Pathology , Bambino Gesù Children's Hospital, IRCCS , Rome , Italy.
⁵ e Research Laboratories, Bambino Gesù Children's Hospital, IRCCS , Rome , Italy.

PMID: 28093006
DOI: 10.1080/10428194.2016.1274980

No abstract available

Publication types

Letter

MeSH terms

Alleles
Amino Acid Sequence
Amino Acid Substitution
Cell Transformation, Neoplastic / genetics*
Cell Transformation, Neoplastic / metabolism
Core Binding Factor Alpha 1 Subunit / chemistry
Core Binding Factor Alpha 1 Subunit / genetics*
Core Binding Factor Alpha 1 Subunit / metabolism
Core Binding Factor Alpha 2 Subunit / chemistry
Core Binding Factor Alpha 2 Subunit / genetics*
Core Binding Factor Alpha 2 Subunit / metabolism
Hematologic Neoplasms / genetics*
Hematologic Neoplasms / metabolism
Humans
Models, Molecular
Mutation*
Protein Binding
Protein Conformation
Protein Interaction Domains and Motifs
Signal Transduction
Structure-Activity Relationship

Substances

Core Binding Factor Alpha 1 Subunit
Core Binding Factor Alpha 2 Subunit
RUNX1 protein, human
RUNX2 protein, human