The high morbidity and mortality of non-small cell lung cancer (NSCLC) did influence the quality of life of tumor patients world-wide. There is an urgent need to develop new therapies that have high anti-tumor activity and low toxicity side effects. It is widely accepted that autophagy can play diverse roles in carcinogenesis, such as induces pro-death of lung cancer cells or helps the escape from cell death, making it become a proper anticancer target. It's believed that various monomers of Chinese traditional medicine closely correlates to anti-NSCLC activities, and that even could affect the acquired multiple drug resistance (MDR). Furthermore, autophagy might be the underling mechanisms which could play a role as the candidate targets of natural active compounds. Recent studies of terpenoids, alkaloid, dietary polyphenols, saponins and other active ingredients that extracted from a large variety of herbs suggest that different monomer compounds could either regulate the activity of pro-death autophagy or influence the level of protective autophagy of NSCLC cells, thus changing their drug sensitivity and cell viability. This paper aims to give a systemic description of the latest advances about natural compounds and their derivatives that involved in tumorigenesis of NSCLC via inducing the autophagy.
非小细胞肺癌（non-small cell lung cancer, NSCLC）发病率、病死率高，亟待研发高抗癌活性、低毒副作用的新型疗法。自噬既可诱发NSCLC癌细胞死亡又可介导死亡逃避，多样化的角色使之成为抗癌的新机制。天然中药众多活性单体及其衍生物具备抗NSCLC的活性，甚至可影响其获得性耐药，而对自噬的调控多被证实为其潜在的作用机制。针对多种天然药物来源的萜类化合物、生物碱、膳食多酚、皂苷类化合物及其它活性成分的研究证实，不同单体成分既可影响NSCLC保护性自噬水平，亦可调控其死亡性自噬活性，相应的影响NSCLC的生长及对某些药物的反应性。因而，本文就天然中药成分及其衍生物通过双向调节自噬活性参与NSCLC治疗的最新进展做一综述。.