Combating blood stream infections during induction chemotherapy in children with acute myeloid leukemia: Single center results in India

Divya Subburaj; Ramya Uppuluri; Dhaarani Jayaraman; Venkateshwaran Vellaichamyswaminathan; Sathishkumar Kandath; Revathi Raj

doi:10.1002/pbc.26517

Combating blood stream infections during induction chemotherapy in children with acute myeloid leukemia: Single center results in India

Pediatr Blood Cancer. 2017 Oct;64(10). doi: 10.1002/pbc.26517. Epub 2017 Mar 23.

Authors

Divya Subburaj¹, Ramya Uppuluri¹, Dhaarani Jayaraman¹, Venkateshwaran Vellaichamyswaminathan¹, Sathishkumar Kandath², Revathi Raj¹

Affiliations

¹ Department of Pediatric Hematology, Oncology and Blood and Marrow Transplantation, Apollo Speciality Hospital, Chennai, India.
² Department of Pediatric Critical Care Group, Apollo Speciality Hospital, Chennai, India.

PMID: 28332765
DOI: 10.1002/pbc.26517

Abstract

Optimal management of infectious complication is the biggest challenge in children receiving chemotherapy for acute myeloid leukemia (AML). We have analyzed the data of children undergoing AML induction chemotherapy at our center from 2002 to 2016 and found that Gram-negative infections are more predominant when compared to the published literature. There also has been a surge in multidrug-resistant (MDR) infections over the last 4 years, which has increased the need for supportive care and escalated the cost of care. We have introduced certain novel methods to combat MDR sepsis and decrease mortality rates.

Keywords: AML; BSI; MDR organisms; supportive care.

MeSH terms

Adolescent
Child
Child, Preschool
Costs and Cost Analysis
Drug Resistance, Multiple, Bacterial*
Female
Gram-Negative Bacterial Infections* / drug therapy
Gram-Negative Bacterial Infections* / economics
Humans
India
Infant
Leukemia, Myeloid, Acute* / drug therapy
Leukemia, Myeloid, Acute* / economics
Leukemia, Myeloid, Acute* / microbiology
Male