Asymmetric Notch Amplification to Secure Stem Cell Identity

Anthony M Rossi; Claude Desplan

doi:10.1016/j.devcel.2017.03.010

Asymmetric Notch Amplification to Secure Stem Cell Identity

Dev Cell. 2017 Mar 27;40(6):513-514. doi: 10.1016/j.devcel.2017.03.010.

Authors

Anthony M Rossi¹, Claude Desplan²

Affiliations

¹ Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA.
² Department of Biology, New York University, 1009 Silver Center, 100 Washington Square East, New York, NY 10003, USA. Electronic address: cd38@nyu.edu.

Abstract

Stem cells self-renew and produce progenitors with limited proliferative potential. Reporting in Developmental Cell, Liu et al. (2017) demonstrate that in some neural stem cells, Notch activity is asymmetrically amplified by a positive feedback loop with the super elongation complex (SEC) to quickly differentiate between stem cells and progenitors.

Publication types

Comment

MeSH terms

Cell Differentiation
Neural Stem Cells
Receptors, Notch*
Signal Transduction
Stem Cells*

Substances

Receptors, Notch

Abstract

Publication types

MeSH terms

Substances

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