1 Anaesthesia and Critical Care Group, Division of Clinical Neuroscience, University of Nottingham, Queen's Medical Centre, Nottingham University Hospitals, Nottingham NG7 2UH, UK.
2 Health Services Research Centre, National Institute of Academic Anaesthesia, Royal College of Anaesthetists, Churchill House, 35 Red Lion Square, London WC1R 4SG, UK.
3 University College London Hospitals (UCLH) National Institute for Health Research (NIHR) Surgical Outcomes Research Centre, University College London Department of Applied Health Research, 1-19 Torrington Place, London WC1E, UK.
4 Department of Anaesthesia and Perioperative Medicine, 3rd floor Maples Link Corridor, University College Hospital, 235 Euston Road, London NW1 2BU, UK.
5 Critical Care Research Area, NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton SO16 6YD, UK and.
6 Integrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton SO16 6YD, UK.