An emergency brake for protein synthesis

Elife. 2017 Apr 25:6:e27085. doi: 10.7554/eLife.27085.

Abstract

The integrated stress response is able to rapidly shut down the synthesis of proteins in eukaryotic cells.

Keywords: ISR; S. cerevisiae; biochemistry; chromosomes; eIF2; eIF2B; genes; protein interactions; translational control.

Publication types

  • Comment

MeSH terms

  • Eukaryotic Initiation Factor-2 / genetics*
  • Eukaryotic Initiation Factor-2B / genetics*
  • Phosphorylation
  • Protein Biosynthesis
  • Proteins

Substances

  • Eukaryotic Initiation Factor-2
  • Eukaryotic Initiation Factor-2B
  • Proteins