Neobraclactones A-C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata

Org Biomol Chem. 2017 Jun 7;15(22):4901-4906. doi: 10.1039/c7ob01007a.

Abstract

Neobraclactones A-C (1-3), featuring an unprecedented further rearranged prenylxanthone skeleton with a unique octahydro-2H-1,3-dioxacyclopenta[c,d]inden-2-one scaffold, along with their biosynthesis-related known compound neobractatin (4), were isolated from the leaves of Garcinia bracteata. Their structures with absolute configurations were determined by extensive analyses of spectroscopic data and ECD calculations. Compounds 1 and 2 showed significant growth inhibition activities against the human leukaemia HL-60 and K562 cell lines with GI50 values from 0.40 to 0.86 μM.

MeSH terms

  • Garcinia / chemistry*
  • Molecular Conformation
  • Xanthones / chemistry
  • Xanthones / isolation & purification*

Substances

  • Xanthones