The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade

Anna Schurich; Charles Raine; Vanessa Morris; Coziana Ciurtin

doi:10.1093/rheumatology/kex186

The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade

Rheumatology (Oxford). 2018 Feb 1;57(2):246-254. doi: 10.1093/rheumatology/kex186.

Authors

Anna Schurich¹, Charles Raine², Vanessa Morris², Coziana Ciurtin²

Affiliations

¹ Division of Infection and Immunity, University College London, UK.
² Department of Rheumatology, University College London Hospitals NHS Trust, London, UK.

PMID: 28541488
DOI: 10.1093/rheumatology/kex186

Abstract

In this review we discuss the divergent role of two closely related cytokines, IL-12 and IL-23, in shaping immune responses. In light of current therapeutic developments using biologic agents to block these two pathways, a better understanding of the immunological function of these cytokines is pivotal.

Keywords: IL-12 related immunodeficiency; IL-12/23 blockade; briakinumab; psoriasis; psoriatic arthritis; ustekinumab.

Publication types

Review

MeSH terms

Biological Factors / immunology
Biological Factors / therapeutic use
Chronic Disease
Humans
Immunologic Factors / immunology
Immunologic Factors / therapeutic use
Inflammation / immunology
Inflammatory Bowel Diseases / immunology*
Inflammatory Bowel Diseases / therapy
Interleukin-12 / antagonists & inhibitors
Interleukin-12 / deficiency
Interleukin-12 / immunology*
Interleukin-23 / antagonists & inhibitors
Interleukin-23 / immunology*
Lymphocyte Activation / immunology
Psoriasis / immunology*
Psoriasis / therapy
T-Lymphocytes / immunology*

Substances

Biological Factors
Immunologic Factors
Interleukin-23
Interleukin-12