"Chronic myelogenous leukemia in primary blast crisis" rather than "de novo BCR-ABL1-positive acute myeloid leukemia"

Cedric Pastoret; Roch Houot

doi:10.1002/ccr3.937

"Chronic myelogenous leukemia in primary blast crisis" rather than "de novo BCR-ABL1-positive acute myeloid leukemia"

Clin Case Rep. 2017 Apr 4;5(6):757-760. doi: 10.1002/ccr3.937. eCollection 2017 Jun.

Authors

Cedric Pastoret¹, Roch Houot²

Affiliations

¹ Laboratory of Hematology University Hospital Rennes France.
² Department of Clinical Hematology University Hospital Rennes France.

Abstract

Differentiating chronic myelogenous leukemia in primary blast crisis (CML-BC) from de novo BCR-ABL1-positive acute myeloid leukemia (AML) is a diagnostic challenge with therapeutic consequences. In our case, a basophilia, the presence of the Philadelphia chromosome in all metaphases and the strict exclusion of molecular hallmarks of AML lead us to retain the diagnosis of CML-BC rather than BCR-ABL1+ AML.

Keywords: BCR‐ABL1‐positive acute myeloid leukemia; Basophiloblast; chronic myeloid leukemia.

Publication types

Case Reports