Objective: To explore the related factors for primary hepatic carcinoma (PHC) caused by chronic hepatitis B (CHB) and hepatitis C (CHC). Methods: According to the principle of cross-sectional study, a cluster random sample method was used, a total of 366 chronic hepatitis patients in hospitals were recruited from three provincial tertiary hospitals in Shanxi, Henan and Jilin between July 2016 and October 2016, respectively. Using a self-designed unified questionnaire, face-to-face interviews was conducted on subjects, including sex, age, alcohol consumption, coffee consumption, green tea consumption, fish consumption, smoking, HBV/HCV diagnosis and treatment, diabetes mellitus, family history of PHC (whether PHC in first-degree relatives), etc. Multivariate unconditional logistic regression were performed to identify the related factors for PHC with CHB and CHC. According to the clinical diagnosis the patients were divided into a chronic hepatitis group (not developing to PHC) and a PHC group. Results: Among 366 cases patients, 287 (78.4%) cases were male, 79 cases were female (21.6%), average age was (52.7±9.3) years. 202 cases were chronic hepatitis group, 164 cases were PHC group. Multivariate unconditional logistics regression analysis indicated that alcohol consumption (odds ratio (OR)=2.11, 95%CI: 1.18-3.75), family history of PHC (OR=5.12, 95%CI: 2.60-10.08) were positively correlated with the development of PHC in chronic b, green tea consumption (OR=0.45, 95%CI: 0.23-0.88), antiviral treatment (OR=0.19, 95%CI: 0.11-0.32) were negatively correlated. Alcohol consumption (OR=3.98, 95%CI: 1.14-13.85) was positively correlated with the development of PHC in chronic c, antiviral treatment (OR=0.14, 95%CI: 0.04-0.50) was negatively correlated. Conclusion: Alcohol consumption, family history of PHC, green tea consumption and antiviral treatment were the related factors for the development of PHC in chronic hepatitis b. Alcohol consumption and antiviral treatment were the related factors for the development of PHC in chronic hepatitis c.
目的： 分析慢性乙型和丙型肝炎导致原发性肝癌（PHC）的相关因素。 方法： 于2016年7—10月间，按照横断面研究原则，采用整群抽样方法，分别抽取陕西、河南、吉林各1家省级三甲医院，并以院内所有慢性乙型肝炎和丙型肝炎住院患者为研究对象，共366例。分别依照临床诊断将其分为慢性肝炎组（即未发展为PHC分为慢性乙型肝炎组和慢性丙型肝炎组）和PHC组。采用统一的自行设计的调查问卷，对调查对象进行逐项面对面询问调查，调查内容包括性别、年龄、饮酒、绿茶摄入、咖啡摄入、鱼摄入、吸烟、HBV/HCV诊治情况、糖尿病患病情况、肝癌家族史（一级亲属中是否患有肝癌）等。采用多因素非条件logistic回归模型分析对调查对象由慢性肝炎发展为PHC进行多因素分析。 结果： 366例调查对象中，男性287例（78.4%），女性79例（21.6%），年龄为（52.7±9.3）岁；慢性肝炎组202例，PHC组164例。多因素分析结果显示，饮酒（OR=2.11，95%CI：1.18~3.75）、肝癌家族史（OR=5.12，95%CI：2.60~10.08）与调查对象由慢性乙型肝炎发展为PHC呈正相关，绿茶摄入（OR=0.45，95%CI：0.23~0.88）、抗病毒治疗（OR=0.19，95%CI：0.11~0.32）与其呈负相关；饮酒（OR=3.98，95%CI：1.14~13.85）与调查对象由慢性丙型肝炎发展为PHC呈正相关，抗病毒治疗（OR=0.14，95%CI：0.04~0.50）与其呈负相关。 结论： 饮酒、肝癌家族史、绿茶摄入、抗病毒治疗是慢性乙型肝炎发展为PHC的相关因素；饮酒、抗病毒治疗是丙型肝炎发展为PHC的相关因素。.
Keywords: Hepatitis B virus; Hepatitis C; Liver neoplasms.