Liposome-Coated Persistent Luminescence Nanoparticles as Luminescence Trackable Drug Carrier for Chemotherapy

Anal Chem. 2017 Jul 5;89(13):6936-6939. doi: 10.1021/acs.analchem.7b01397. Epub 2017 Jun 15.

Abstract

Near-infrared persistent luminescence nanoparticles (NIR-PLNPs) are promising imaging agents due to deep tissue penetration, high signal-to-noise ratio, and repeatedly charging ability. Here, we report liposome-coated NIR-PLNPs (Lipo-PLNPs) as a novel persistent luminescence imaging guided drug carrier for chemotherapy. The Lipo-PLNP nanocomposite shows the advantages of superior persistent luminescence and high drug loading efficiency and enables autofluorescence-free and long-term tracking of drug delivery carriers with remarkable therapeutic effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / drug therapy
  • Animals
  • Antineoplastic Agents / therapeutic use
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry*
  • Drug Carriers / toxicity
  • Female
  • Humans
  • Liposomes / chemical synthesis
  • Liposomes / chemistry*
  • Liposomes / toxicity
  • Luminescent Agents / chemistry*
  • Luminescent Agents / toxicity
  • MCF-7 Cells
  • Mice, Inbred BALB C
  • Nanocomposites / chemistry*
  • Nanocomposites / toxicity
  • Nanoparticles / chemistry*
  • Nanoparticles / toxicity
  • Paclitaxel / therapeutic use

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Liposomes
  • Luminescent Agents
  • Paclitaxel