Five-year follow-up study of tardive dyskinesia

Adv Biochem Psychopharmacol. 1985:40:37-42.

Abstract

A 5-year follow-up investigation of TD was carried out in 85 Hungarian schizophrenic out-patients. No substantial changes occurred during the 5 years in pharmacotherapy: most patients continued on neuroleptics and antiparkinson drugs. Comparison of 1978 and 1983 ratings revealed increased dyskinesia scores, which was statistically significant on the DRS Choreo-athetosis cluster. There was an increase in the number of patients with "moderately" severe TD from 4 in 1978 to 6 in 1981 to 10 (9 "Moderate" and 1 "Severe" TD) in 1983. The total number of TD cases as defined by research diagnostic criteria increased by only 3. The long-term trend in these neuroleptic-treated schizophrenics is for dyskinesia to plateau after reaching mild intensity, while in a minority of cases, the dyskinesia tends to extend from the oro-facial region to other body regions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antipsychotic Agents / adverse effects*
  • Dyskinesia, Drug-Induced / diagnosis*
  • Follow-Up Studies
  • Humans
  • Schizophrenia / drug therapy*

Substances

  • Antipsychotic Agents