Physiology and pathophysiology of excitation-contraction coupling: the functional role of ryanodine receptor

J Muscle Res Cell Motil. 2017 Feb;38(1):37-45. doi: 10.1007/s10974-017-9470-z. Epub 2017 Jun 26.

Abstract

Calcium (Ca2+) release from intracellular stores plays a key role in the regulation of skeletal muscle contraction. The type 1 ryanodine receptors (RyR1) is the major Ca2+ release channel on the sarcoplasmic reticulum (SR) of myocytes in skeletal muscle and is required for excitation-contraction (E-C) coupling. This article explores the role of RyR1 in skeletal muscle physiology and pathophysiology.

Keywords: Calcium; Excitation–contraction coupling; Muscular dystrophy; RyR1; Skeletal muscle.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / metabolism
  • Excitation Contraction Coupling / physiology*
  • Homeostasis
  • Humans
  • Ryanodine Receptor Calcium Release Channel / metabolism*

Substances

  • Ryanodine Receptor Calcium Release Channel
  • Calcium