Combined effect of anti-BAG3 and anti-PD-1 treatment on macrophage infiltrate, CD8⁺ T cell number and tumour growth in pancreatic cancer

Gut. 2018 Apr;67(4):780-782. doi: 10.1136/gutjnl-2017-314225. Epub 2017 Aug 11.

Authors

Vittoria Iorio^#^{1

2}, Alessandra Rosati^#^{1

2}, Raffaella D'Auria^{1

2}, Margot De Marco^{1

2}, Liberato Marzullo^{1

2}, Anna Basile^{1

2}, Michelina Festa^{1

3}, Maria Pascale^{1

3}, Paolo Remondelli², Mario Capunzo², Gianluca Sala⁴, Verena Damiani⁴, Giuseppina Amodio², Marta Di Nicola⁴, Rossano Lattanzio⁴, Maria Caterina Turco^{1

2}, Vincenzo De Laurenzi^{1

4}

Affiliations

¹ Biouniversa srl, c/o University of Salerno, Montoro, Avellino, Italy.
² Department of Medicine, Surgery and Dentistry, Schola Medica Salernitana, University of Salerno, Baronissi, Salerno, Italy.
³ Department of Pharmacy, Division of Biomedicine 'A Leone', University of Salerno, Fisciano, Salerno, Italy.
⁴ Department of Medicine and Biotechnology, University G d'Annunzio and CeSI-MeT, Chieti, Italy.

^# Contributed equally.

No abstract available

Keywords: immunotherapy; macrophages; pancreatic cancer; t lymphocytes.

Publication types

Comment

MeSH terms

Adaptor Proteins, Signal Transducing
Apoptosis Regulatory Proteins
CD8-Positive T-Lymphocytes
Cell Count
Humans
Immunotherapy
Macrophages*
Pancreatic Neoplasms*
Programmed Cell Death 1 Receptor

Substances

Adaptor Proteins, Signal Transducing
Apoptosis Regulatory Proteins
BAG3 protein, human
Programmed Cell Death 1 Receptor