High-dimension single-cell analysis applied to cancer

Abstract

High-dimension single-cell technology is transforming our ability to study and understand cancer. Numerous studies and reviews have reported advances in technology development. The biological insights gleaned from single-cell technology about cancer biology are less reviewed. Here we focus on research studies that illustrate novel aspects of cancer biology that bulk analysis could not achieve, and discuss the fresh insights gained from the application of single-cell technology across basic and clinical cancer studies.

Keywords: Cell identity; Correlation analysis; Single-cell analysis; Subclone phylogeny; Tumor ecosystem; Tumor heterogeneity.