Relationship of genetic causes and inhibin B in non obstructive azoospermia spermatogenic failure

BMC Med Genet. 2017 Sep 6;18(1):98. doi: 10.1186/s12881-017-0456-x.

Abstract

Background: Chromosomal disorders in non obstructive azoospermia (NOA) may have an important influence on spermatogenesis, which may be reflected by the serum inhibin B levels. Till now, few studies have concerned the relationship of genetic causes and inhibin B in NOA.

Methods: In this retrospective study, 322 men with NOA in Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University were collected. The level of follicle stimulating hormone (FSH), inhibin B, Y chromosome microdeletion test (YCMD) and karyotype were measured.

Results: Abnormal karyotypes were present in 38.5% of NOA, and YCMD were present in 18.0%, there was a high correlation between karyotypes and YCMD (χ2 = 11.892, P < 0.001). The level of inhibin B in chromosomal abnormality from lowest to highest was 46,XX (or 45,X), 47, XXY, mosaics, polymorphisms, inversion and translocation. And the level of inhibin B within Non-AZF a&b region deletion was higher than AZF a&b microdeletion.

Conclusion: According to the level of inhibin B, spermatogenesis in chromosomal abnormality from lowest to highest was 46,XX (or 45,X), 47, XXY, mosaics, polymorphisms, inversion and translocation. And spermatogenesis within Non-AZF a&b region deletion was better than AZF a&b microdeletion.

Keywords: Inhibin B; Karyotype; Non obstruction azoospermia; Y chromosome microdeletion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Azoospermia / blood
  • Azoospermia / genetics*
  • Chromosome Deletion
  • Chromosomes, Human, Y
  • Follicle Stimulating Hormone
  • Humans
  • Inhibins / blood*
  • Karyotyping
  • Male
  • Retrospective Studies
  • Sex Chromosome Aberrations
  • Spermatogenesis / genetics

Substances

  • inhibin B
  • Inhibins
  • Follicle Stimulating Hormone

Supplementary concepts

  • Azoospermia, Nonobstructive