Chromosome 17 markers and von Recklinghausen neurofibromatosis: a genetic linkage study in a British population

M Upadhyaya; M Sarfarazi; S M Huson; K Stephens; W Broadhead; P S Harper

doi:10.1016/0888-7543(87)90038-3

Chromosome 17 markers and von Recklinghausen neurofibromatosis: a genetic linkage study in a British population

Genomics. 1987 Dec;1(4):358-60. doi: 10.1016/0888-7543(87)90038-3.

Authors

M Upadhyaya¹, M Sarfarazi, S M Huson, K Stephens, W Broadhead, P S Harper

Affiliation

¹ Institute of Medical Genetics, University of Wales College of Medicine, Health Park, Cardiff, United Kingdom.

PMID: 2896630
DOI: 10.1016/0888-7543(87)90038-3

Abstract

A genetic linkage study of the RFLPs identified by nine DNA probes localized to the pericentromeric region and long arm of chromosome 17 has been undertaken in 16 families with von Recklinghausen neurofibromatosis (NF1). Close linkage has been shown with the markers CRI-L946 (D17S36), CRI-L581 (D17S37), p17H8 (D17Z1), and pA10-41 (D17S71). The ERBA1 and COL1A1 loci may also be closely linked, but the data are limited. The results for HOX2 and NGFR suggest only loose linkage with the NF1 gene, while no linkage was found between NF1 and the growth hormone locus. No suggestion of nonallelic heterogeneity of NF1 was found in this study.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosomes, Human, Pair 17*
Genetic Markers
Humans
Lod Score
Neurofibromatosis 1 / genetics*
Polymorphism, Restriction Fragment Length

Substances

Genetic Markers