More Alcohol, More Liver Injury: Not Always True

Alcohol Alcohol. 2017 Nov 1;52(6):627-628. doi: 10.1093/alcalc/agx064.

Abstract

An animal model of alcoholic liver disease (ALD) that recapitulates human disease is an unmet need. An alcohol-preferring strain and WT mice were fed alcohol by different techniques and with different diet compositions. Interestingly, the greatest alcohol consumers did not develop the worst ALD. This editorial highlights how diet and the gut microbiome/metabolome may influence the development/severity of ALD.

Publication types

  • Review

MeSH terms

  • Alcohol Drinking / adverse effects*
  • Alcohol Drinking / genetics
  • Alcohol Drinking / physiopathology*
  • Animals
  • Disease Models, Animal*
  • Gastrointestinal Microbiome / physiology
  • Humans
  • Liver Diseases, Alcoholic / etiology*
  • Liver Diseases, Alcoholic / genetics
  • Liver Diseases, Alcoholic / physiopathology*
  • Mice
  • Risk Factors