Chromosomal assignment of a glutamic acid transfer RNA (tRNAGlu) gene to 1p36

Hum Genet. 1989 Jan;81(2):153-6. doi: 10.1007/BF00293892.

Abstract

A gene for tRNAGlu has been assigned to human chromosome 1p36 by in situ hybridisation using a [3H]-labelled or biotinylated 2.4-kb (human) DNA fragment containing a tRNAGlu gene as a probe. With the biotinylated DNA probe a secondary statistically significant site of hybridisation was observed at 1q21-22 which might represent a pseudogene or related sequence. In fibroblasts from gorilla (Gorilla gorilla) using biotin labelling, a single site of hybridisation occurred at 1qter which provides further support for homology of 1q in the higher apes and human 1p.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence*
  • Chromosome Banding
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 1*
  • DNA Probes
  • Gorilla gorilla
  • Humans
  • Karyotyping
  • Nucleic Acid Hybridization
  • RNA, Transfer, Amino Acid-Specific / genetics*
  • RNA, Transfer, Glu / genetics*
  • Sequence Homology, Nucleic Acid*

Substances

  • DNA Probes
  • RNA, Transfer, Amino Acid-Specific
  • RNA, Transfer, Glu